The Assessment of the Relation between Il-6 174 G/c, Il-6 190 G/c, Il-6 572 G/c Genes Polymorphisms and Nutritional Status Disorders in a Child Population from Romania

Background Nutritional disorders are plurifactorial diseases in which the genetic aspects have an important role near the lifestyle and dietary habits. The systemic inflammation and cytokines levels are much studied in the etipatogenity of these diseases. We aimed to assess the relation between IL6-174G/C,IL6-190T/C andIL6-572G/C genes polimorphisms and nutritional status in a group of pediatric patients. Methods The study included 385 patients: 173 malnourished, 102 obese and 110 controls in terms of genetic, biochemical and antropometric tests. Results For IL6-174G/Cgene, in obese, predominated of CG genotype (p=0.001); CC genotype was a protective factor, in malnourished, GG and CG genotypes (p=0.0001). Regarding IL6-190T/C gene, genotype CC was more frequent in obese (p=0.0001), in malnourished, CT heterozygotes (p=0.003), and TT genotype having protective function. Analysing IL6-572G/Cgene polimorphisms, CC genotype was more frequent in obese (p=0.0001), GG predominated in both malnourished and controls. BMI, MUAC, TST and albumine levels correlated with CC genotype of IL6-190 and IL6-572 genes in obese, while in malnourished, they correlated with GG and CG genotypes of IL6-174 and IL6-572 genes and with CT genotype of IL6-190 gene. Conclusion: Child nutritional disorders were more frequent associated with IL6-174 G allele carriers. The highest risk of developing obesity was found in C-carriers of IL6-572 gene; CC genotype of IL6-174 may be a protective factor for obesity, while IL6-190 TT genotype could have protective function for malnutrition. Further research would establish the role of certain gene constellations in nutritional status disorders.